Validation of standard operating procedures in a multicenter retrospective study to identify -omics biomarkers for chronic low back pain
Identifieur interne : 000078 ( Main/Exploration ); précédent : 000077; suivant : 000079Validation of standard operating procedures in a multicenter retrospective study to identify -omics biomarkers for chronic low back pain
Auteurs : Concetta Dagostino [Italie] ; Manuela De Gregori [Italie] ; Christian Gieger [Allemagne] ; Judith Manz [Allemagne] ; Ivan Gudelj [Croatie] ; Gordan Lauc [Croatie] ; Laura Divizia [Italie] ; Wei Wang [Australie] ; Moira Sim [Australie] ; Iain K. Pemberton [France] ; Jane Macdougall [France] ; Frances Williams [Royaume-Uni] ; Jan Van Zundert [Belgique] ; Dragan Primorac [Croatie, États-Unis] ; Yurii Aulchenko [Pays-Bas] ; Leonardo Kapural [États-Unis] ; Massimo Allegri [Italie]Source :
- PLoS ONE [ 1932-6203 ] ; 2017.
Descripteurs français
- KwdFr :
- Aire sous la courbe, Analyse chimique du sang (normes), Analyse multivariée, Australie, Carboxypeptidases (sang), Courbe ROC, Douleur chronique (génétique), Douleur chronique (métabolisme), Douleur chronique (sang), Europe, Humains, Lombalgie (génétique), Lombalgie (métabolisme), Lombalgie (sang), Marqueurs biologiques (sang), Polyosides (sang), Prélèvement sanguin (normes), États-Unis d'Amérique, Études rétrospectives.
- MESH :
- génétique : Douleur chronique, Lombalgie.
- métabolisme : Douleur chronique, Lombalgie.
- normes : Analyse chimique du sang, Prélèvement sanguin.
- sang : Carboxypeptidases, Douleur chronique, Lombalgie, Marqueurs biologiques, Polyosides.
- Aire sous la courbe, Analyse multivariée, Australie, Courbe ROC, Europe, Humains, États-Unis d'Amérique, Études rétrospectives.
English descriptors
- KwdEn :
- Area Under Curve, Australia, Biomarkers (blood), Blood Chemical Analysis (standards), Blood Specimen Collection (standards), Carboxypeptidases (blood), Chronic Pain (blood), Chronic Pain (genetics), Chronic Pain (metabolism), Europe, Humans, Low Back Pain (blood), Low Back Pain (genetics), Low Back Pain (metabolism), Multivariate Analysis, Polysaccharides (blood), ROC Curve, Retrospective Studies, United States.
- MESH :
- chemical , blood : Biomarkers, Carboxypeptidases, Polysaccharides.
- blood : Chronic Pain, Low Back Pain.
- genetics : Chronic Pain, Low Back Pain.
- metabolism : Chronic Pain, Low Back Pain.
- standards : Blood Chemical Analysis, Blood Specimen Collection.
- Area Under Curve, Australia, Europe, Humans, Multivariate Analysis, ROC Curve, Retrospective Studies, United States.
Abstract
Chronic low back pain (CLBP) is one of the most common medical conditions, ranking as the greatest contributor to global disability and accounting for huge societal costs based on the Global Burden of Disease 2010 study.
Large genetic and -omics studies provide a promising avenue for the screening, development and validation of biomarkers useful for personalized diagnosis and treatment (precision medicine). Multicentre studies are needed for such an effort, and a standardized and homogeneous approach is vital for recruitment of large numbers of participants among different centres (clinical and laboratories) to obtain robust and reproducible results. To date, no validated standard operating procedures (SOPs) for genetic/-omics studies in chronic pain have been developed.
In this study, we validated an SOP model that will be used in the multicentre (5 centres) retrospective “PainOmics” study, funded by the European Community in the 7th Framework Programme, which aims to develop new biomarkers for CLBP through three different -omics approaches: genomics, glycomics and activomics.
The SOPs describe the specific procedures for (
Multivariate analysis revealed the absolute specificity and homogeneity of the samples collected by the five centres for all genetics, glycomics and activomics analyses.
The SOPs used in our multicenter study have been validated. Hence, they could represent an innovative tool for the correct management and collection of reliable samples in other large-omics-based multicenter studies.
Url:
DOI: 10.1371/journal.pone.0176372
PubMed: 28459826
PubMed Central: 5411039
Affiliations:
- Allemagne, Australie, Belgique, Croatie, France, Italie, Pays-Bas, Royaume-Uni, États-Unis
- Angleterre, Caroline du Nord, Grand Londres, Groningue (province), Pennsylvanie
- Groningue, Londres, University Park (Pennsylvanie)
- Université d'État de Pennsylvanie
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Le document en format XML
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Ziekenhuis Oost-Limburg, Genk, Belgium</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Anesthesiology, Critical Care and Multidisciplinary Pain Center, Ziekenhuis Oost-Limburg, Genk</wicri:regionArea><wicri:noRegion>Genk</wicri:noRegion></affiliation></author><author><name sortKey="Primorac, Dragan" sort="Primorac, Dragan" uniqKey="Primorac D" first="Dragan" last="Primorac">Dragan Primorac</name><affiliation wicri:level="1"><nlm:aff id="aff010"><addr-line>St. Catherine Specialty Hospital, Zabok, Croatia</addr-line></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>St. Catherine Specialty Hospital, Zabok</wicri:regionArea><wicri:noRegion>Zabok</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff011"><addr-line>Eberly College of Science, The Pennsylvania State University, University Park, Pennsylvania, United States of America</addr-line></nlm:aff><country 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last="Kapural">Leonardo Kapural</name><affiliation wicri:level="2"><nlm:aff id="aff016"><addr-line>Carolinas Pain Institute, Winston-Salem, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Carolinas Pain Institute, Winston-Salem, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Allegri, Massimo" sort="Allegri, Massimo" uniqKey="Allegri M" first="Massimo" last="Allegri">Massimo Allegri</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Anesthesia, Critical Care and Pain Medicine Unit, Division of Surgical Sciences, Department of Medicine and Surgery, University of Parma, Parma, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Anesthesia, Critical Care and Pain Medicine Unit, Division of Surgical Sciences, Department of Medicine and Surgery, University of Parma, 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Dagostino</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Anesthesia, Critical Care and Pain Medicine Unit, Division of Surgical Sciences, Department of Medicine and Surgery, University of Parma, Parma, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Anesthesia, Critical Care and Pain Medicine Unit, Division of Surgical Sciences, Department of Medicine and Surgery, University of Parma, Parma</wicri:regionArea><wicri:noRegion>Parma</wicri:noRegion></affiliation></author><author><name sortKey="De Gregori, Manuela" sort="De Gregori, Manuela" uniqKey="De Gregori M" first="Manuela" last="De Gregori">Manuela De Gregori</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>PainTherapy Service, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>PainTherapy Service, Fondazione IRCCS Policlinico San Matteo, Pavia</wicri:regionArea><wicri:noRegion>Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Institute of Epidemiology II, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Manz, Judith" sort="Manz, Judith" uniqKey="Manz J" first="Judith" last="Manz">Judith Manz</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Institute of Epidemiology II, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Gudelj, Ivan" sort="Gudelj, Ivan" uniqKey="Gudelj I" first="Ivan" last="Gudelj">Ivan Gudelj</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Genos, Glycoscience Research Laboratory, Zagreb, Croatia</addr-line></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Genos, Glycoscience Research Laboratory, Zagreb</wicri:regionArea><wicri:noRegion>Zagreb</wicri:noRegion></affiliation></author><author><name sortKey="Lauc, Gordan" sort="Lauc, Gordan" uniqKey="Lauc G" first="Gordan" last="Lauc">Gordan Lauc</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Genos, Glycoscience Research Laboratory, Zagreb, Croatia</addr-line></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Genos, Glycoscience Research Laboratory, Zagreb</wicri:regionArea><wicri:noRegion>Zagreb</wicri:noRegion></affiliation></author><author><name sortKey="Divizia, Laura" sort="Divizia, Laura" uniqKey="Divizia L" first="Laura" last="Divizia">Laura Divizia</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Laboratory of Biochemistry and Genetics, Division of Pneumology, Department of Molecular Medicine, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratory of Biochemistry and Genetics, Division of Pneumology, Department of Molecular Medicine, Fondazione IRCCS Policlinico San Matteo, Pavia</wicri:regionArea><wicri:noRegion>Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Wei" sort="Wang, Wei" uniqKey="Wang W" first="Wei" last="Wang">Wei Wang</name><affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia</wicri:regionArea><wicri:noRegion>Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Sim, Moira" sort="Sim, Moira" uniqKey="Sim M" first="Moira" last="Sim">Moira Sim</name><affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia</wicri:regionArea><wicri:noRegion>Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Pemberton, Iain K" sort="Pemberton, Iain K" uniqKey="Pemberton I" first="Iain K." last="Pemberton">Iain K. Pemberton</name><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>IP Research Consulting SASU (PHOTEOMIX) - Rex de Chaussée, Noisy le Grand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>IP Research Consulting SASU (PHOTEOMIX) - Rex de Chaussée, Noisy le Grand</wicri:regionArea><wicri:noRegion>Noisy le Grand</wicri:noRegion><wicri:noRegion>Noisy le Grand</wicri:noRegion></affiliation></author><author><name sortKey="Macdougall, Jane" sort="Macdougall, Jane" uniqKey="Macdougall J" first="Jane" last="Macdougall">Jane Macdougall</name><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>IP Research Consulting SASU (PHOTEOMIX) - Rex de Chaussée, Noisy le Grand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>IP Research Consulting SASU (PHOTEOMIX) - Rex de Chaussée, Noisy le Grand</wicri:regionArea><wicri:noRegion>Noisy le Grand</wicri:noRegion><wicri:noRegion>Noisy le Grand</wicri:noRegion></affiliation></author><author><name sortKey="Williams, Frances" sort="Williams, Frances" uniqKey="Williams F" first="Frances" last="Williams">Frances Williams</name><affiliation wicri:level="3"><nlm:aff id="aff008"><addr-line>Department of Twin Research and Genetic Epidemiology, King’s College London, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Van Zundert, Jan" sort="Van Zundert, Jan" uniqKey="Van Zundert J" first="Jan" last="Van Zundert">Jan Van Zundert</name><affiliation wicri:level="1"><nlm:aff id="aff009"><addr-line>Department of Anesthesiology, Critical Care and Multidisciplinary Pain Center, Ziekenhuis Oost-Limburg, Genk, Belgium</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Anesthesiology, Critical Care and Multidisciplinary Pain Center, Ziekenhuis Oost-Limburg, Genk</wicri:regionArea><wicri:noRegion>Genk</wicri:noRegion></affiliation></author><author><name sortKey="Primorac, Dragan" sort="Primorac, Dragan" uniqKey="Primorac D" first="Dragan" last="Primorac">Dragan Primorac</name><affiliation wicri:level="1"><nlm:aff id="aff010"><addr-line>St. Catherine Specialty Hospital, Zabok, Croatia</addr-line></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>St. Catherine Specialty Hospital, Zabok</wicri:regionArea><wicri:noRegion>Zabok</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff011"><addr-line>Eberly College of Science, The Pennsylvania State University, University Park, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Eberly College of Science, The Pennsylvania State University, University Park, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">University Park (Pennsylvanie)</settlement></placeName><orgName type="university">Université d'État de Pennsylvanie</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff012"><addr-line>University of Split School of Medicine, Split, Croatia</addr-line></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>University of Split School of Medicine, Split</wicri:regionArea><wicri:noRegion>Split</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff013"><addr-line>University of Osijek School of Medicine, Osijek, Croatia</addr-line></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>University of Osijek School of Medicine, Osijek</wicri:regionArea><wicri:noRegion>Osijek</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff014"><addr-line>Children's Hospital Srebrnjak, Zagreb, Croatia</addr-line></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>Children's Hospital Srebrnjak, Zagreb</wicri:regionArea><wicri:noRegion>Zagreb</wicri:noRegion></affiliation></author><author><name sortKey="Aulchenko, Yurii" sort="Aulchenko, Yurii" uniqKey="Aulchenko Y" first="Yurii" last="Aulchenko">Yurii Aulchenko</name><affiliation wicri:level="3"><nlm:aff id="aff015"><addr-line>PolyOmica, Groningen, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>PolyOmica, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Kapural, Leonardo" sort="Kapural, Leonardo" uniqKey="Kapural L" first="Leonardo" last="Kapural">Leonardo Kapural</name><affiliation wicri:level="2"><nlm:aff id="aff016"><addr-line>Carolinas Pain Institute, Winston-Salem, North Carolina, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Carolinas Pain Institute, Winston-Salem, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Allegri, Massimo" sort="Allegri, Massimo" uniqKey="Allegri M" first="Massimo" last="Allegri">Massimo Allegri</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Anesthesia, Critical Care and Pain Medicine Unit, Division of Surgical Sciences, Department of Medicine and Surgery, University of Parma, Parma, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Anesthesia, Critical Care and Pain Medicine Unit, Division of Surgical Sciences, Department of Medicine and Surgery, University of Parma, Parma</wicri:regionArea><wicri:noRegion>Parma</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Area Under Curve</term><term>Australia</term><term>Biomarkers (blood)</term><term>Blood Chemical Analysis (standards)</term><term>Blood Specimen Collection (standards)</term><term>Carboxypeptidases (blood)</term><term>Chronic Pain (blood)</term><term>Chronic Pain (genetics)</term><term>Chronic Pain (metabolism)</term><term>Europe</term><term>Humans</term><term>Low Back Pain (blood)</term><term>Low Back Pain (genetics)</term><term>Low Back Pain (metabolism)</term><term>Multivariate Analysis</term><term>Polysaccharides (blood)</term><term>ROC Curve</term><term>Retrospective Studies</term><term>United States</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Aire sous la courbe</term><term>Analyse chimique du sang (normes)</term><term>Analyse multivariée</term><term>Australie</term><term>Carboxypeptidases (sang)</term><term>Courbe ROC</term><term>Douleur chronique (génétique)</term><term>Douleur chronique (métabolisme)</term><term>Douleur chronique (sang)</term><term>Europe</term><term>Humains</term><term>Lombalgie (génétique)</term><term>Lombalgie (métabolisme)</term><term>Lombalgie (sang)</term><term>Marqueurs biologiques (sang)</term><term>Polyosides (sang)</term><term>Prélèvement sanguin (normes)</term><term>États-Unis d'Amérique</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term><term>Carboxypeptidases</term><term>Polysaccharides</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Chronic Pain</term><term>Low Back Pain</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Chronic Pain</term><term>Low Back Pain</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Douleur chronique</term><term>Lombalgie</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Chronic Pain</term><term>Low Back Pain</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Douleur chronique</term><term>Lombalgie</term></keywords><keywords scheme="MESH" qualifier="normes" xml:lang="fr"><term>Analyse chimique du sang</term><term>Prélèvement sanguin</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Carboxypeptidases</term><term>Douleur chronique</term><term>Lombalgie</term><term>Marqueurs biologiques</term><term>Polyosides</term></keywords><keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Blood Chemical Analysis</term><term>Blood Specimen Collection</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Area Under Curve</term><term>Australia</term><term>Europe</term><term>Humans</term><term>Multivariate Analysis</term><term>ROC Curve</term><term>Retrospective Studies</term><term>United States</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Aire sous la courbe</term><term>Analyse multivariée</term><term>Australie</term><term>Courbe ROC</term><term>Europe</term><term>Humains</term><term>États-Unis d'Amérique</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Chronic low back pain (CLBP) is one of the most common medical conditions, ranking as the greatest contributor to global disability and accounting for huge societal costs based on the Global Burden of Disease 2010 study.</p><p>Large genetic and -omics studies provide a promising avenue for the screening, development and validation of biomarkers useful for personalized diagnosis and treatment (precision medicine). Multicentre studies are needed for such an effort, and a standardized and homogeneous approach is vital for recruitment of large numbers of participants among different centres (clinical and laboratories) to obtain robust and reproducible results. To date, no validated standard operating procedures (SOPs) for genetic/-omics studies in chronic pain have been developed.</p><p>In this study, we validated an SOP model that will be used in the multicentre (5 centres) retrospective “PainOmics” study, funded by the European Community in the 7th Framework Programme, which aims to develop new biomarkers for CLBP through three different -omics approaches: genomics, glycomics and activomics.</p><p>The SOPs describe the specific procedures for (<italic>1</italic>) blood collection, (<italic>2</italic>) sample processing and storage, (<italic>3</italic>) shipping details and (<italic>4</italic>) cross-check testing and validation before assays that all the centres involved in the study have to follow.</p><p>Multivariate analysis revealed the absolute specificity and homogeneity of the samples collected by the five centres for all genetics, glycomics and activomics analyses.</p><p>The SOPs used in our multicenter study have been validated. Hence, they could represent an innovative tool for the correct management and collection of reliable samples in other large-omics-based multicenter studies.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chou, R" uniqKey="Chou R">R Chou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Freburger, Jk" uniqKey="Freburger J">JK Freburger</name></author><author><name sortKey="Holmes, Gm" uniqKey="Holmes G">GM Holmes</name></author><author><name sortKey="Agans, Rp" uniqKey="Agans R">RP Agans</name></author><author><name sortKey="Jackman, Am" uniqKey="Jackman A">AM Jackman</name></author><author><name sortKey="Darter, Jd" uniqKey="Darter J">JD Darter</name></author><author><name sortKey="Wallace, As" uniqKey="Wallace A">AS Wallace</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meucci, Rd" uniqKey="Meucci R">RD Meucci</name></author><author><name sortKey="Fassa, Ag" 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last="De Gregori">Manuela De Gregori</name><name sortKey="Divizia, Laura" sort="Divizia, Laura" uniqKey="Divizia L" first="Laura" last="Divizia">Laura Divizia</name></country><country name="Allemagne"><noRegion><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name></noRegion><name sortKey="Manz, Judith" sort="Manz, Judith" uniqKey="Manz J" first="Judith" last="Manz">Judith Manz</name></country><country name="Croatie"><noRegion><name sortKey="Gudelj, Ivan" sort="Gudelj, Ivan" uniqKey="Gudelj I" first="Ivan" last="Gudelj">Ivan Gudelj</name></noRegion><name sortKey="Lauc, Gordan" sort="Lauc, Gordan" uniqKey="Lauc G" first="Gordan" last="Lauc">Gordan Lauc</name><name sortKey="Primorac, Dragan" sort="Primorac, Dragan" uniqKey="Primorac D" first="Dragan" last="Primorac">Dragan Primorac</name><name sortKey="Primorac, Dragan" sort="Primorac, Dragan" uniqKey="Primorac D" first="Dragan" last="Primorac">Dragan Primorac</name><name sortKey="Primorac, Dragan" sort="Primorac, Dragan" uniqKey="Primorac D" first="Dragan" last="Primorac">Dragan Primorac</name><name sortKey="Primorac, Dragan" sort="Primorac, Dragan" uniqKey="Primorac D" first="Dragan" last="Primorac">Dragan Primorac</name></country><country name="Australie"><noRegion><name sortKey="Wang, Wei" sort="Wang, Wei" uniqKey="Wang W" first="Wei" last="Wang">Wei Wang</name></noRegion><name sortKey="Sim, Moira" sort="Sim, Moira" uniqKey="Sim M" first="Moira" last="Sim">Moira Sim</name></country><country name="France"><noRegion><name sortKey="Pemberton, Iain K" sort="Pemberton, Iain K" uniqKey="Pemberton I" first="Iain K." last="Pemberton">Iain K. Pemberton</name></noRegion><name sortKey="Macdougall, Jane" sort="Macdougall, Jane" uniqKey="Macdougall J" first="Jane" last="Macdougall">Jane Macdougall</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Williams, Frances" sort="Williams, Frances" uniqKey="Williams F" first="Frances" last="Williams">Frances Williams</name></region></country><country name="Belgique"><noRegion><name sortKey="Van Zundert, Jan" sort="Van Zundert, Jan" uniqKey="Van Zundert J" first="Jan" last="Van Zundert">Jan Van Zundert</name></noRegion></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Primorac, Dragan" sort="Primorac, Dragan" uniqKey="Primorac D" first="Dragan" last="Primorac">Dragan Primorac</name></region><name sortKey="Kapural, Leonardo" sort="Kapural, Leonardo" uniqKey="Kapural L" first="Leonardo" last="Kapural">Leonardo Kapural</name></country><country name="Pays-Bas"><region name="Groningue (province)"><name sortKey="Aulchenko, Yurii" sort="Aulchenko, Yurii" uniqKey="Aulchenko Y" first="Yurii" last="Aulchenko">Yurii Aulchenko</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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